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Notable Paper: Virally Delivered Channelrhodopsin-2 Safely and Effectively...

This truly groundbreaking paper by M Mehdi Doroudchi, Kenneth P Greenberg, Jianwen Liu, Kimberly A Silka, Edward S Boyden, Jennifer A Lockridge, A Cyrus Arman, Ramesh Janani, Shannon E Boye, Sanford L...

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Retinoid Receptors Trigger Neuritogenesis in Retinal Degenerations

This paper by Y Lin, BW Jones, A Liu, JF Tucker, K Rapp, L Luo, W Baehr, PS Bernstein, CB Watt, JH Yang, MV Shaw and RE Marc examines the neuronal sprouting or neuritogenesis components of retinal...

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Proliferative reactive gliosis is compatible with glial metabolic support...

This paper by Vazquez-Chona FR, Swan A, Ferrell WD, Jiang L, Baehr W, Chien WM, Fero M, Marc RE and Levine EM addresses a long standing issue in the field of neuroscience: is the reactive phenotype of...

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Notable Paper: Long-term RNA interference gene therapy in a dominant...

Hereditary retinal dystrophies (retinitis pigmentosa, Leber congenital amaurosis, cone-rod dystrophies, macular degeneration) are characterized by loss of visual function, sometimes starting during...

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Notable Paper: Gene Therapy Rescues Photoreceptor Blindness in Dogs and Paves...

This paper in PNAS by William A. Beltran, Artur V. Cideciyan, Alfred S. Lewin, Simone Iwabe, Hemant Khanna, Alexander Sumaroka, Vince A. Chiodo, Diego S. Fajardo, Alejandro J. Román, Wen-Tao Deng,...

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Dysmorphic Photoreceptors in a P23H Mutant Rhodopsin Model of Retinitis...

This paper (and the cover article) is the result of a collaborative effort between Damian C. Lee, Felix R. Vazquez-Chona, W. Drew Ferrell, Beatrice M. Tam, Bryan W. Jones, Robert E. Marc, and Orson L....

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Photovoltaic Retinal Prosthesis With High Pixel Density

Retinas are complex systems and engineered rescues of vision loss through bionic means have to date been inelegant solutions.  Retinal bionic implants have historically not been successes due to some...

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Full-Length Axon Regeneration In The Adult Mouse Optic Nerve and Partial...

Friend of Webvision Yves Sauvé sent in this paper by Silmara de Lima, Yoshiki Koriyama, Takuji Kurimoto, Julia Teixeira Oliveira, Yuqin Yin, Yiqing Li, Hui-Ya Gilbert, Michela Fagiolini, Ana Maria...

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Moran Eye Center International Outreach

Here on Webvision, our goal is retinal education and even though Webvision is hosted here at the Moran Eye Center, we nevertheless try to include as much of the wider community as possible in posts and...

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Interesting Article: Mechanism of RPE Cell Death in α-Crystallin Deficient...

I ran across an interesting paper in PLOS One published back in March of 2012 by Parameswaran G. Sreekumar, Christine Spee, Stephen J. Ryan, Susan P. C. Cole, Ram Kannan and David R. Hinton.  This...

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Notable Papers: An Easier Way To Make Stem Cells?

We’ve talked about work out of the RIKEN Institute before here on Webvision.  The work that comes out of there is clever and often unconventional.  The latest work from the RIKEN that seems to have...

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The Judgment Of Solomon

I had the honor and privilege of attending a Lasker/IRRF Initiative’s plenary session on Restoring Vision to the Blind at Janelia Farm last month where Mr. Sanford D. Greenberg delivered an emotional...

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Portrait Of Vision Scientist: Ann Morris

Ann Morris from the University of Kentucky studies the zebrafish (Danio rerio).  In particular, she studies the ability of zebrafish retinas to regenerate following retinal injury or damage.  Retinal...

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Lasker/IRRF Report On Restoring Vision

I participated in the Lasker/IRRF Initiative on Restoring Vision to the Blind in March 2014. It was a great session of research leaders working on various approaches to restore visual function lost by...

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New Webvision Chapter: Retinal Degeneration, Remodeling and Plasticity

We have a new Webvision chapter on Retinal Degeneration, Remodeling and Plasticity! Check it out here.

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